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. 2021 Feb 10;22(4):1755. doi: 10.3390/ijms22041755

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of saline, probenecid and tonabersat combination and probenecid on immunoreactivity of light-damaged rats. Light-induced damage increased expression of Cx43 (green) in the ganglion cell layer (a). Probenecid and/or tonabersat treated rats showed less Cx43 immunoreactivity in the retina (b,c) compared to saline treated rats (a). Iba-1 immuno-labelled cells (green, highlighted by white arrows) were fewer in number in the retina of probenecid treated rats (e) and tonabersat and probenecid (f) compared to saline-treated rats (d). GFAP (red) immunoreactivity did not increase in the retina of probenecid treated rats (h) nor in the tonabersat and probenecid treatments (i) compared to saline-treated rats (g). Abbreviation: GCL, ganglion cell layer; IPL, inner plexiform layer; INL, inner nuclear layer; ONL, outer nuclear layer. Scale bar: 50 μm.