Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 10;22(4):1755. doi: 10.3390/ijms22041755

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Overall analysis of the mixed a-wave amplitude which deflects downwards (a) and b-wave amplitude which deflects upwards (b) of the ERG for each of the connexin or pannexin blockers (or combination) applied to the light-damaged rat retina. The a-wave and b-wave amplitude in the ERGs improved towards the normal retinal function ranges for all the Cx43 hemichannel blocking treatments trialed compared to probenecid, which significantly ameliorated the response, but not to a normal level. Statistical analysis was conducted using one-way ANOVA, followed by a post-hoc test comparing computer-generated normal ERG values with treatment values. The normality values were randomly selected between −400 to −700 µV for the a-wave, and between 400 to 700 µV for the b-wave [46]. The boxed area shows treatments that preserved retinal function and were non-significantly different from normal values. Abbreviations: i.v., intravitreal; i.p. intraperitoneal; np, nanoparticles; Pro, probenecid; Ton, tonabersat; p.b. peanut butter.