Table 1.

Summary of our published data reporting a therapeutic effect in the light-damaged rat model after intervention with Cx43 hemichannel blockers (tonabersat or Peptide5) with specific delivery methods.

Intervention	Delivery	Animals	Timeline	References
Control (vehicle)	Systemic (intraperitoneal and oral); ocular (intravitreal)	6	Follow up at 24 h, 1 week, 2 weeks, 3 months	[13,14,15,16]
Cx43 mimetic peptide (Peptide5)	Ocular (two intravitreal injections, one at 2 h and the other immediately after 24 h light exposure)	6	Follow up for 24 h	[14]
Peptide5	Ocular (one intravitreal injection)	6	Follow up at 24 h, 1 week and 2 weeks	[16]
Peptide5 in nanoparticles	Ocular (one intravitreal injection)	6	Follow up at 24 h, 1 week and 2 weeks	[16]
Tonabersat	Systemic (intraperitoneal injection at 2 h and immediately after 24 h light exposure)	6	Follow up at 24 h, 1 week and 2 weeks	[15]
Tonabersat	Systemic (oral administration immediately before starting light exposure)	6	Follow up at 24 h, 1 week, 2 weeks, 3 months	[13]