Table 1.
Nucleocytoplasmic transport factors with examples of their cargoes.
| Transport Factor | Cargoes |
|---|---|
| Exportins | |
| Exportin-1 (Crm1) | Leucin-rich NES cargoes, NF-kB, Cyclin D1, NFAT, p53, p21, IkB, BCR-ABL, FOXO3a, TOPO IIa, eIF4E, HIV genomic RNA |
| Cellular apoptosis susceptibility (CAS/XPO2) | Importin alpha |
| Exportin-t | tRNA |
| Exportin 5 | Pre-microRNA, tRNA, eEF-1A, ILF3, Staufen2, dsRNA-binding proteins, 60S pre-ribosomal subunits |
| Exportin 6 | Profilin, Actin |
| Exportin 7 | P50Rho-GAP, Histone 2A, Histone H3, 14-3-3 |
| Importins | |
| Importin β1 | Cargos with basic NLs via importin alpha, NFAT, PRPF31, CREB, p65, β-catenin, JAK1, STAT5, cyclin B1, SRY/SOX-9, PTHrP |
| Importin β2 | Histone, ribosomal proteins, FOXO4, FUS, hnRNAPA1 |
| Importin β3 | c-Jun, Histones, ribosomal proteins, IRF3, RASAL2, HPV E5 (16E2) |
| Importin 3 | HuR |
| Importin 4 | HIF1-alpha, Histones, ribosomal proteins, Vitamin D receptor |
| Importin 7 | c-Jun, CREB, Ribosomal proteins, SMAD3, HIV RTC, GR, Histone H1 |
| Importin 8 | SMADs, eIF4E, Signal Recognition Particle Protein 19 |
| Importin 9 | c-Jun, PP2A (PR65), NUAK1, nuclear actin, Histone, ribosomal proteins, |
| Importin 11 | UBE2E3, UBE2E1, PTEN, β-catenin, UBcM2, rpL12 |
| Importin 12 | SRSF1, CIRBP |
| Import/Export | |
| Importin 13 | Import: c-Jun, Mago-Y14, RBM8, Ubc9, Glucocorticoid Receptor, Pax6 Export: eIF1A |
| Exportin 4 | Import: Sox2, SRY Export: SMAD3, eIF5A |
| Non-characterized | |
| Ran BP6 | Undefined |
| Ran BP17 | Undefined |