Table 3.
Descriptive statistics of data from Macrod1 accelerated rotarod. Mean ± SEM is presented. Individual N number is included as well as p-values for all terms and interactions. Statistics was performed on all factors combined using a factorial-ANOVA, whereas separated by sex and age cohort comparisons used an ANCOVA (weight as a covariable). The difference between the means is presented alongside a Cohen’s d-score to demonstrate effect size.
| Macrod1 Rotarod |
AGE | Latency to Fall (s) | ||||
|---|---|---|---|---|---|---|
| WT | Macrod1 KO | Difference | d-Score | ANCOVA p-Value |
||
| Female | 12 months | 193.3 ± 12.7 | 146.0 ± 15.2 | 47.3 | 0.788 | F(1,27) = 14.53, * p = 0.005 |
| n = 13 | n = 17 | |||||
| Male | 121.7 ± 10.7 | 117.1 ± 14.9 | 4.6 | 0.090 | F(1,22) = 0.53, p = 0.473 | |
| n = 19 | n = 15 | |||||
| Female | 18 months | 123.8 ± 14.5 | 103.18 ± 9.52 | 20.62 | 0.408 | F(1,29) = 3.11, p = 0.089 |
| n = 17 | n = 15 | |||||
| Male | 76.51 ± 5.05 | 78.92 ± 7.94 | 2.41 | 0.106 | F(1,22) = 0.15, p = 0.703 | |
| n = 13 | n = 12 | |||||
| Genotype | F(1,110) = 5.82, * p = 0.018 | |||||
| Sex | F(1,110) = 7.75, * p = 0.006 | |||||
| Cohort | F(1,110) = 3.66, p = 0.058 | |||||
| Genotype*Sex | F(1,110) = 0.01, p = 0.939 | |||||
| Sex*Cohort | F(1,110) = 2.36, p = 0.128 | |||||
| Weight | F(1,110) = 33.92, * p < 0.001 | |||||
| Weight*Sex | F(1,110) = 8.04, * p = 0.005 | |||||
| Weight*Cohort | F(1,110) = 2.50, p = 0.117 | |||||
| Weight*Genotype | F(1,110) = 4.13, * p = 0.045 | |||||
| Genotype*Cohort | F(1,110) = 0.01, p = 0.977 | |||||