Table 5.

Descriptive statistics of distance travelled data from Macrod2 distance travelled Y-maze preference test. Mean ± SEM is presented. Individual N number is included as well as p-values for all terms and interactions. Statistics were performed on all factors combined using a factorial-ANOVA with repeated measures hence the term Mouse name. x = not an exact F-test. Separated by sex and age cohort comparisons used an ANCOVA (weight as a covariable). The difference between the means is presented alongside a Cohen’s d-score to demonstrate effect size.

Macrod2 Y-Maze	AGE	Total Distance (m) (2 min)
		WT	Macrod2 KO	Difference (s)	Cohen’s d	p-Value
Female	3 months	6.328 ± 0.247	6.189 ± 0.490	0.139	0.094	F(1,29) = 1.46, p = 0.505
		n = 17	n = 15
Male		5.652 ± 0.284	6.524 ± 0.394	0.872	0.560	F(1,30) = 2.38, p = 0.133
		n = 13	n = 20
Female	13 months	3.743 ± 0.239	4.638 ± 0.452	0.895	0.560	F(1,29) = 6.09, * p = 0.020
		n = 16	n = 16
Male		3.659 ± 0.308	3.933 ± 0.308	0.274	0.237	F(1,27) = 0.10, p = 0.759
		n = 13	n = 17
Genotype		F(1,51) = 5.74, * p = 0.019 x
Sex		F(1,51) = 0.46, p = 0.499 x
Genotype*Sex		F(1,51) = 0.07, p = 0.796 x
Cohort		F(1,51) = 0.03, p = 0.868
Weight		F(1,51) = 0.31, p = 0.581
Weight*Sex		F(1,51) = 0.57, p = 0.456
Weight*Cohort		F(1,51) = 0.05, p = 0.826
Sex*Cohort		F(1,51) = 0.26, p = 0.610
Genotype*Cohort		F(1,51) = 0.59, p = 0.447
Mouse name		F(1,51) = 0.95, p = 0.589