Table 6.

Descriptive statistics of gait velocity from the Macrod2 catwalk gait analysis. Mean ± SEM is presented. Individual N number is included as well as p-values for all terms and interactions. Statistics were performed on all factors combined using a factorial-ANOVA with repeated measures hence the term Mouse name. x = not an exact F-test. Separated by sex and age cohort comparisons used an ANCOVA (weight as a covariable). The difference between the means is presented alongside a Cohen’s d-score to demonstrate effect size.

Macrod2 Catwalk	AGE	Gait Velocity (cm/s)
		WT	Macrod2 KO	Difference (cm/s)	Cohen’s d	p-Value
Female	3 months	27.586 ± 0.926	25.84 ± 1.36	1.746	0.358	F(1,34) = 1.15, p = 0.290
		n = 20	n = 17
Male		27.339 ± 0.818	22.917 ± 0.751	4.422	1.188	F(1,27) = 15.09, * p = 0.001
		n = 13	n = 17
Female	13 months	21.707 ± 0.805	19.701 ± 0.717	2.006	0.633	F(1,29) = 4.33, * p = 0.046
		n = 16	n = 16
Male		22.192 ± 0.800	19.263 ± 0.831	2.929	0.842	F(1,27) = 7.98, * p = 0.009
		n = 13	n = 17
Genotype		F(1,54) = 13.69, * p < 0.001 x
Sex		F(1,54) = 0.97, p = 0.330 x
Genotype*Sex		F(1,54) = 3.31, p = 0.073 x
Cohort		F(1,54) = 0.93, p = 0.339
Weight		F(1,54) = 2.89, p = 0.095
Weight*Sex		F(1,54) = 0.39, p = 0.535
Weight*Cohort		F(1,54) = 0.54, p = 0.467
Sex*Cohort		F(1,54) = 0.14, p = 0.708
Genotype*Cohort		F(1,54) = 0.35, p = 0.558
Mouse Name		F(1,54) = 1.48, p = 0.069