Table 7.
Descriptive statistics of SQRT gait cadence from the Macrod2 catwalk gait analysis. SQRT = square root transformed. Mean ± SEM is presented. Individual N number is included as well as p-values for all terms and interactions. Statistics were performed on all factors combined using a factorial-ANOVA with repeated measures hence the term Mouse Name. x = not an exact F-test. Separated by sex and age cohort comparisons used an ANCOVA (weight as a covariable). The difference between the means is presented alongside a Cohen’s d-score to demonstrate effect size.
| Macrod2 Catwalk |
AGE | SQRT Gait Cadence (Steps/Minute) | ||||
|---|---|---|---|---|---|---|
| WT | Macrod2 KO | Difference | Cohen’s d | p-Value | ||
| Female | 3 months | 4.1927 ± 0.0449 n = 20 |
4.1121 ± 0.0606 n = 17 |
0.0806 | 0.358 | F(1,34) = 1.16, p = 0.289 |
| Male | 4.0171 ± 0.0530 n = 13 |
3.8959 ± 0.0461 n = 17 |
0.1212 | 0.616 | F(1,27) = 3.00, p = 0.095 | |
| Female | 13 months | 3.7722 ± 0.0521 n = 16 |
3.6424 ± 0.0429 n = 16 |
0.1298 | 0.653 | F(1,29) = 2.20, p = 0.149 |
| Male | 3.7295 ± 0.0614 n = 13 |
3.6475 ± 0.0586 n = 17 |
0.082 | 0.352 | F(1,27) = 1.71, p = 0.202 | |
| Genotype | F(1,54) = 5.15, * p = 0.026 x | |||||
| Sex | F(1,54) = 0.59, p = 0.445 x | |||||
| Genotype*Sex | F(1,54) = 0.52, p = 0.473 x | |||||
| Cohort | F(1,54) = 0.46, p = 0.499 | |||||
| Weight | F(1,54) = 4.47, * p = 0.039 | |||||
| Weight*Sex | F(1,54) = 0.20, p = 0.659 | |||||
| Weight*Cohort | F(1,54) = 0.20, p = 0.658 | |||||
| Sex*Cohort | F(1,54) = 0.96, p = 0.330 | |||||
| Genotype*Cohort | F(1,54) = 0.01, p = 0.903 | |||||
| Mouse Name | F(1,54) = 1.92, * p = 0.007 | |||||