Table 8.
Descriptive statistics of forefoot swing speed from the Macrod2 catwalk gait analysis. Mean ± SEM is presented. Individual N number is included as well as p-values for all terms and interactions. Statistics were performed on all factors combined using a factorial-ANOVA with repeated measures hence the term Mouse Name. x = not an exact F-test. Separated by sex and age cohort comparisons used an ANCOVA (weight as a covariable). The difference between the means is presented alongside a Cohen’s d-score to demonstrate effect size.
| Macrod2 Catwalk |
Forefoot Swing Speed (cm/s) | |||||
|---|---|---|---|---|---|---|
| AGE | WT | Macrod2 KO | Difference (cm/s) | Cohen’s d | p-Value | |
| Female | 3 months | 60.67 ± 1.43 n = 20 |
57.92 ± 2.68 n = 17 |
2.75 | 0.311 | F(1,34) = 0.639, p = 0.359 |
| Male | 63.32 ± 1.45 n = 13 |
56.22 ± 1.51 n = 17 |
7.1 | 1.053 | F(1,27) = 10.82, * p = 0.003 | |
| Female | 13 months | 49.57 ± 1.43 n = 16 |
48.41 ± 1.51 n = 16 |
1.16 | 0.200 | F(1,29) = 1.86, p = 0.183 |
| Male | 54.37 ± 1.93 n = 13 |
48.07 ± 1.38 n = 17 |
6.3 | 0.912 | F(1,27) = 7.26, * p = 0.012 | |
| Genotype | F(1,54) = 11.93, * p = 0.001 x | |||||
| Sex | F(1,54) = 1.65, p = 0.204 x | |||||
| Genotype*Sex | F(1,54) = 3.31, p = 0.073 x | |||||
| Cohort | F(1,54) = 1.22, p = 0.275 | |||||
| Weight | F(1,54) = 1.52, p = 0.224 | |||||
| Weight*Sex | F(1,54) = 0.81, p = 0.373 | |||||
| Weight*Cohort | F(1,54) = 0.57, p = 0.452 | |||||
| Sex*Cohort | F(1,54) = 0.07, p = 0.790 | |||||
| Genotype*Cohort | F(1,54) = 0.14, p = 0.706 | |||||
| Mouse Name | F(1,54) = 1.33, p = 0.143 | |||||