Table 9.
Descriptive statistics of forefoot stride length from the Macrod2 catwalk gait analysis. Mean ± SEM is presented. Individual N number is included as well as p-values for all terms and interactions. Statistics were performed on all factors combined using a factorial-ANOVA with repeated measures hence the term Mouse Name. x = not an exact F-test. Separated by sex and age cohort comparisons used an ANCOVA (weight as a covariable). The difference between the means is presented alongside a Cohen’s d-score to demonstrate effect size.
| Macrod2 Catwalk |
AGE | Forefoot Stride Length (cm) | ||||
|---|---|---|---|---|---|---|
| WT | Macrod2 KO | Difference (cm/s) | Cohen’s d | p-Value | ||
| Female | 3 months | 6.166 ± 0.113 n = 20 |
5.934 ± 0.200 n = 17 |
0.232 | 0.345 | F(1,34) = 1.07, p = 0.309 |
| Male | 6.755 ± 0.118 n = 13 |
5.989 ± 0.100 n = 17 |
0.766 | 1.361 | F(1,27) = 23.85, * p > 0.001 |
|
| Female | 13 months | 6.078 ± 0.149 n = 16 |
5.838 ± 0.145 n = 16 |
0.240 | 0.406 | F(1,29) = 3.63, p = 0.067 |
| Male | 6.3687 ± 0.0804 n = 13 |
5.816 ± 0.134 n = 17 |
0.5527 | 1.045 | F(1,27) = 10.32, * p = 0.003 | |
| Genotype | F(1,54) = 18.48, * p < 0.001 x | |||||
| Sex | F(1,54) = 2.28, p = 0.137 x | |||||
| Genotype*Sex | F(1,54) = 4.70, * p = 0.033 x | |||||
| Cohort | F(1,54) = 0.41, p = 0.526 | |||||
| Weight | F(1,54) = 0.77, p = 0.383 | |||||
| Weight*Sex | F(1,54) = 1.23, p = 0.271 | |||||
| Weight*Cohort | F(1,54) = 0.40, p = 0.529 | |||||
| Sex*Cohort | F(1,54) = 0.00, p = 0.988 | |||||
| Genotype*Cohort | F(1,54) = 0.14, p = 0.715 | |||||
| Mouse Name | F(1,54) = 1.53, p = 0.054 | |||||