Table 1.
In vitro fungicidal activity of KP and its derivatives against Candida albicans SC5314.
| Peptide | Sequence | MM 1 (Da) | EC50 2 (95 % Confidence Intervals) [mol/liter] × 10−6 | EC50 Derivatives/EC50 KP |
|---|---|---|---|---|
| A10S (KP) | AKVTMTCSAS | 998.17 | 0.673 (0.633–0.716) | - |
| H10S | HKVTMTCSAS | 1064.21 | 0.343 (0.331–0.357) | 0.51 |
| K10S | KKVTMTCSAS | 1055.26 | 0.277 (0.274–0.279) | 0.41 |
| L10S | LKVTMTCSAS | 1040.25 | 1.344 (1.246–1.450) | 2.00 |
| P10S | PKVTMTCSAS | 1024.21 | 0.676 (0.615–0.742) | 1.00 |
| S10S | SKVTMTCSAS | 1014.17 | 0.761 (0.587–0.986) | 1.13 |
| Y10S | YKVTMTCSAS | 1090.26 | 0.847 (0.766–0.936) | 1.26 |
| K9S | KVTMTCSAS | 927.09 | 0.863 (0.653–1.141) | 1.28 |
1 MM, molecular mass (dalton) calculated by the ExPASy tool ProtParam; 2 EC50, half maximal effective concentration, expressed in mol/liter × 10−6. In parentheses, 95% confidence intervals.