Table 2.
Neutralization of in vitro candidacidal activity of KP and KP-derivatives by laminarin.
| C. albicans Growth Inhibition (%) in the Presence of | |||
|---|---|---|---|
| Peptide | µg/mL 1 | Laminarin 100 µg/mL | Laminarin 200 µg/mL |
| A10S (KP) | 5.00 | 96.39 ± 1.68 | 1.80 ± 0.49 |
| H10S | 2.00 | 6.20 ± 3.71 | n.d. |
| K10S | 1.25 | 1.07 ± 0.39 | n.d. |
| L10S | 5.00 | 0 | n.d. |
| P10S | 5.00 | 97.71 ± 0.46 | 3.10 ± 4.38 |
| S10S | 5.00 | 99.12 ± 0.50 | 60.73 ± 13.13 |
| Y10S | 5.00 | 5.57 ± 4.84 | n.d. |
| K9S | 5.00 | 31.09 ± 1.71 | 0.68 ± 0.97 |
1 Each peptide was tested at its minimal candidacidal concentration, i.e., the concentration yielding no colonies (100% inhibition) in the CFU assay performed as described in Material and Methods section. n.d. = not determined.