Table 1. Summary of active sites of HCTs.

Position	Amino acid	Annotation	Reference
31	Val	Shikimate binding	Walker et al. (2013)
32	Pro	Shikimate binding	Walker et al. (2013)
298	Ala	Shikimate binding	Walker et al. (2013)
318	Ile	Shikimate binding	Walker et al. (2013)
376	Phe	Shikimate binding	Walker et al. (2013)
414	Leu	Shikimate binding	Walker et al. (2013), Lallemand et al. (2012)
418	Leu	Shikimate binding	Walker et al. (2013)
38	Ser	carbonyl group of p- coumaroyl moiety	Walker et al. (2013); Eudes et al. (2016)
40	Tyr	carbonyl group of p- coumaroyl moiety	Walker et al. (2013), Lallemand et al. (2012), Eudes et al. (2016)
384	Trp	carbonyl group of p- coumaroyl moiety	Walker et al. (2013)
163	His	carbonyl group of shikimate moiety and Catalysis	Walker et al. (2013), Lallemand et al. (2012), Eudes et al. (2016)
369	Arg	carbonyl group of shikimate moiety	Walker et al. (2013)
382	Thr	carbonyl group of shikimate moiety	Walker et al. (2013), Eudes et al. (2016)
36	Thr	Catalysis	Walker et al. (2013)

Notes.

All positions correspond to SbHCT.