Table 1.
Cases of relapse of neonatal Echerichia coli meningitis.
| Case | First E. coli Meningitis | Relapse E. coli Meningitis | Follow-Up | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sex | GA at birth (weeks) |
BW (gram) |
Age (days) |
Treatment | Cerebral MRI | Urinary ultra-sound | Time from completion (days) | Treatment | Age (years) |
Under-lying disease | Sequelae * | |
| 1 | F | 36 + 3 | 2130 | 3 | Cefotaxime 21 days + gentamicin day 1–5 |
Minor hemorrhagic parenchymal infarctions. No signs of infection. (without contrast) |
Normal | 4 | Meropenem 1 week followed by ceftriaxone 9 weeks |
4.0 | No | No |
| 2 | M | 34 + 0 | 1980 | 5 | Cefotaxime 21 days + gentamicin day 1–3 |
Normal (with contrast) |
Normal | 11 | Cefotaxime 1 week, meropenem 1 week followed by ceftriaxone 12 weeks |
3.5 | No | No |
| 3 | M | 34 + 5 | 2280 | 45 | Cefotaxime 20 days + gentamicin day 1–7 |
Ischemic changes of cortical parenchyma. No signs of infection. (without contrast) |
Normal | 28 | Ceftriaxone 8 weeks | 3.5 | No | Moderate sensory disabilities, visual impairment, delayed development. No signs of hydrocephalus or cerebral palsy. Persistent changes on MRI. |
| 4 | F | 37 + 1 | 2940 | 13 | Cefotaxime 22 days + gentamicin day 1–3 |
Minor hemorrhagic parenchymal infarctions. No signs of infection. (without contrast) |
Normal | 2 | Meropenem + ciprofloxacin 6 weeks followed by ceftriaxone 3 weeks |
4.0 | No | No |
F = Female; M = Male; GA = Gestational Age; BW = Birth Weight; MRI = Magnetic Resonance Imaging. * Developmental milestones and audiology were investigated, in addition to signs of cerebral palsy and hydrocephalus.