Table 1.
Summary of pathway analysis perturbations with halogenated acetic acids (HAA) exposure.
| Compound | Exposure Concentration (mg/L) | Impacted Pathway | p Value |
|---|---|---|---|
| DCAA | 20.65 | The citric acid (TCA) cycle | 0.0761 |
| Purine metabolism | 0.0828 | ||
| TCAA | 8.86 | Nicotinate and nicotinamide metabolism Ubiquinone and other terpenoid-quinone biosynthesis Phenylalanine, tyrosine and tryptophan biosynthesis Phenylalanine metabolism Valine, leucine and isoleucine degradation Valine, leucine and isoleucine biosynthesis Pantothenate and CoA biosynthesis Tyrosine metabolism The citric acid (TCA) cycle Histidine metabolism Glycerophospholipid metabolism Thiamine metabolism Aminoacyl-tRNA biosynthesis Butanoate metabolism Cysteine and methionine metabolism |
≤0.10 |
| DBAA | 7.45 | Thiamine metabolism | 0.0536 |
| Tyrosine metabolism | 0.0571 | ||
| The citric acid (TCA) cycle | 0.0840 | ||
| 14.91 | Purine metabolism | 0.0810 |