Table 1.

Toxic effects of some of the most representative OCFs applied in sunscreen formulations.

OCFs	UV Range	Photodegradation	Toxic Effects
AVOB	357	yes	Suppression of human trophoblast cells and apoptosis mediated by mitochondrial disruption [27], induction of obesogenic phenotypes [28], and hormone-like activity [29].
HS	295–315	no	Skin penetration [30], disrupts estrogen [31].
OMC	280–355	yes	Skin penetration, hormone like-activity; reproductive system, thyroid, and behavioral alterations in animal studies [17].
OB	270–350	yes	Estrogenic activity, alteration of sperm production in the animal associated with endometriosis in women [32].

AVOB: avobenzone. HS: homosalate. OMC: octyl methoxycinnamate. OB: oxybenzone.