Table 2.

Distribution, physiological response, and associated pathology in the renal dopaminergic receptors.

RECEPTOR	D1-Like		D2-Like
	D1	D5	D2	D3	D4
Nephron distribution	Collecting duct. Distal tubule (including medullary thick ascending limb) [56]. Macula densa. Juxtaglomerular cell. Proximal tubule	Collecting duct. Distal tubule (including medullary thick ascending limb) [56]. Proximal tubule	Collecting Duct. Distal tubule. Proximal tubule. Glomerulus	Collecting duct. Distal tubule (including medullary thick ascending limb) [56]. Cortical thick ascending limb. Macula densa. Juxtaglomerular cell. Proximal tubule. Glomerulus	Collecting duct. Distal tubule (including medullary thick ascending limb) [56]. Proximal tubule. Glomerulus
Physiological responses	Inhibition of sodium transport in kidneys [57,58] and gastrointestinal tract. Vasodilation. Inhibition of AT1 receptor expression	Inhibition of sodium transport in kidneys and AT1 receptor expression [58]	Inhibition of sodium transport in kidneys.Antagonizes angiotensin II [59]	Inhibition of sodium transport in kidney [60].Inhibition of AT1 receptor expression and renin excretion. Vasodilation	Antagonize vasopressin- and aldosterone-dependent water and sodium reabsorption in the cortical collecting duct [61]. Inhibition of AT1 receptor expression
Characteristics of gene knockout mice	Hypertension. Sodium retention	Hypertension. Increased sympathetic activity. Sodium retention	Hypertension. Sodium retention	Hypertension. Sodium retention. Increased activities of α-adrenergic and ETB receptors	Hypertension with increased renal AT1 receptor expression