Table 1.
Placental inhibitory immune checkpoint receptor/ligand partners.
| Receptors | Ligands | ||
|---|---|---|---|
| Protein | Gene | Protein | Gene |
| PD1 | PDCD1 | PD-L1 | CD274 |
| PD-L2 | PDCD1LG2 | ||
| CTLA4 | CTLA4 | B7-1 | CD80 |
| B7-2 | CD86 | ||
| ICOS | ICOS | B7-H2 | ICOSLG |
| B7-H3 | CD276 | ||
| B7-H4 | VTCN1 | ||
| B7-H5 | C10orf54 | B7-H5 | C10orf54 (VSIR) |
| TMIGD2 | TMIGD2 | B7-H7 | HHLA2 |
| TIM3 | HAVCR2 | GAL9 | LGALS9 |
| CEACAM1 | CEACAM1 | ||
| HMGB1 | HMGB1 | ||
| LAG3 | LAG3 | FGL1 | FGL1 |
| GAL3 | LGALS3 | ||
| CLEC4G | CLEC4G | ||
| TIGIT | TIGIT | CD155 | PVR |
| CD112 | PVRL2 (NECTIN2) | ||
| CD200R1 | CD200R1 | CD200 | CD200 |
| BTLA | BTLA | HVEM | TNFRSF14 |
| SIRPα | SIRPA | CD47 | CD47 |