Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 10;11(2):274. doi: 10.3390/diagnostics11020274

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Summary of the role of miR-146a in lung cancer. The upregulation of miR-146a in lung cancer has a preventive role by acting as an antiproliferative and proapoptotic agent, anti-inflammatory agent, and metastatic modulator. Various downstream targets mentioned in the figure have been identified in different in vitro and in vivo models, justifying these properties of miR-146a. EGFR: epidermal growth factor receptor; EMMPRIN: extracellular matrix metalloproteinase inducer; MIF: macrophage migration inhibitory factor; IRS2: insulin receptor substrate 2; Merlin/NF2: moesin-ezrin-radixin-like protein/neurofibromatosis type 2; IRAK1: interleukin-1 receptor-associated kinase 1; TRAF6: tumor necrosis factor receptor (TNFR)-associated factor 6; IL-1α: interleukin 1α; IL-1β: interleukin 1β; IL-8: interleukin 8; TNF-α: tumor necrosis factor; COX-2: cyclooxygenase-2; PGE2: prostaglandin E2; LTB4: leukotriene B4; RANTES; regulated on activation, normal T cell expressed and secreted; ATG12: autophagy related 12; JNK2: c-Jun N-terminal kinases; Bcl2: B-cell lymphoma 2; CEACAM6: carcinoembryonic antigen-related cell adhesion molecule 6.