Skip to main content
. 2021 Feb 10;22(4):1763. doi: 10.3390/ijms22041763

Figure 3.

Figure 3

(A) The partial agonist TAK-875 seems to enter its allosteric binding pocket (site A) in an unusual way, most likely through the lipid layer, sneaking into the receptor transmembrane region. (B) Detailed view on binding pose of TAK-875 with the head group buried in the receptor transmembrane region. Hydrogen bonding pattern of TAK-875 with key residues in its allosteric binding pocket shown as dashed lines. This figure was prepared using The PyMOL Molecular Graphics System, Version 2.0 Schrödinger, LLC (New York, NY, USA).