Figure 4.

An interhelical sliding of TM5 in relation to TM4 leads to a translocation of Leu190^5.46. This generates a deep hydrophobic pocket to accommodate the CF3 moiety of the full allosteric agonist AP8 binding to the second allosteric binding pocket (site B). Binary complex of FFAR1 and MK-8666 (PDB ID: 5TZR) shown in grey and ternary complex, consisting of FFAR1, MK-8666, and AP8, (PDB ID: 5TZY) is depicted in blue. This figure was prepared using The PyMOL Molecular Graphics System, Version 2.0 Schrödinger, LLC (New York, NY, USA).