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. 2021 Feb 10;10(2):141. doi: 10.3390/biology10020141

Figure 11.

Figure 11

Changes in the cytokine profile of mice after injection of native CIMVs, CIMVs-BFP or CIMVs-IL2 using the Bio-Plex Pro Mouse Cytokine 23-plex panel. After 72 h, the levels of pro-inflammatory cytokines IL3 (a), IL13 (b) and monocyte chemoattractant protein 1 (MCP-1) (c) were significantly increased in the mice injected with native CIMVs and CIMVs-BFP compared to the PBS group. At the same time, in mice injected with CIMVs-IL2, those cytokine levels remained similar to the PBS control group. The level of granulocyte colony-stimulating factor (G-CSF) (d), which is involved in the immune response to viral and bacterial infections, was reduced in mice treated with native CIMVs and CIMVs-BFP compared to CIMVs-IL2 or PBS only. The secretion of eotaxin (e), which is a chemo attractant for eosinophils in autoimmune inflammation, was re-duced after the administration of CIMVs-IL2 compared to injection with the other CIMVs or PBS. Each box represents the mean ± SD (n = 4) of four biological replicates. p < 0.05, * p < 0.01, ns—not significant.