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In a pre-clinical swine study of chronic myocardial ischemia, administration of CoQ10 (400 mg/day) in the chow for 4 weeks increased the expression of activated PGC1-alpha, the master switch for mitochondrial biogenesis, leading to enhanced expression of mitochondrial antioxidant proteins in the chronically ischemic territory. The data support the concept that CoQ10 is protective by transcriptionally regulating antioxidant proteins in heart tissue. * p < 0.05.
