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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: J Biomol Struct Dyn. 2020 Jul 28;39(16):6084–6098. doi: 10.1080/07391102.2020.1797539

Figure 2: Multiple Sequence Alignment of CEACAM molecules and the structures of the conserved N-terminal domain.

Figure 2:

(A) Domains of CEACAM molecules. The motifs of CEACAM1, 5 and 6 are shown schematically. The sequence of the N-terminal domain, Ig-like V set, of CEACAM1 (P13688), CEACAM5 (P06731) and CEACAM6 (P40199) are aligned, together with the sequence retrieved from the 3D structure of the CEACAM1 N-terminal domain (PDB: 5DZL Chain A). The predicted MHC class I and II restricted epitopes are highlighted. (B) The protein sequence of the antigen (Chain A in 5DZL). The yellow highlighted regions are the MHC I restricted epitopes obtained from the epitope prediction servers. The red highlighted region represents the MHC II restricted epitopes. The overlapping regions have been colored using yellow text. (C) Three-dimensional structure of the antigen (5DZL, Chain A). The MHC I and II restricted epitopes in the antigen structure are colored with the same coloring scheme as (B).