Table 1.

Key features of T-2307.

Mechanism of Action	Causes the collapse of the mitochondrial membrane potential by targeting respiratory chain enzymatic complexes III and IV in the inner mitochondrial membrane of yeasts.
Spectrum of Activity	Candida species, including azole- and echinocandin-resistant isolates, Cryptococcus neoformans & C. gattii. Variable activity against Aspergillus species. Limited in vitro data against fungi suggests limited to no activity against Fusarium, Scedosporium, and the Mucorales.
In vivo activity	Efficacy in murine models of invasive candidiasis caused by C. albicans, C. glabrata, and C. auris; reductions in the ocular fungal burden caused by C. albicans. Efficacy in murine models of systemic aspergillosis due to Aspergillus fumigatus and cryptococcosis caused by C. neoformans and C. gattii.
Pharmacokinetic and clinical data	Not currently available in the literature.