Figure 3.

Summary of the interaction of antioxidant groups found in natural plants and the different metabolic pathways to induce anti obesogenic effects. The numbers correspond to the natural product and the “**” correspond to the enzymes stimulated by Nrf2. Abbreviations: Ang II = Angiotensin II, eNOS = endothelial nitric oxide synthase, H₂O₂ = hydrogen peroxide, GLUT 4 = glucose transporter type 4, GR = glutathione reductase, GSH = glutathione, GSSG = oxidized glutathione, IGF-1 = insulin-like growth factor 1, IGF-1R = insulin-like growth factor 1 receptor, IL = Interleukin, IR = insulin receptor, IRS 1 = insulin receptor substrate 1, LR = Leptin receptor, NF-κB = nuclear factor κ-light-chain-enhancer of activated B cells, NOS = nitric oxide synthase, NOX = nicotinamide adenine dinucleotide phosphate oxidase, O²⁻ = superoxide anion, PI3k = phosphoinositide 3-kinase, PPAR = peroxisome proliferator–activated receptor, PPP = pentose phosphate patway, ROS = reactive oxygen species, SOD = superoxide dismutase, TNF-α = factor de necrosis tumoral alfa.