Table 4.
Associations of symptom clusters, health-related quality of life, and clinical blood markers.
| Subgroups | Variables | Mean (SD) | Spearman’s Rho | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PCS-12 | MCS-12 | WBC | hs-CRP | TSH | Free T4 | Insulin | IGF-1 | |||
| High symptoms burden | 1. PCS-12 | 35.33 (9.89) | 1 | 0.093 ** | −0.049 | −0.038 | 0.043 | −0.083 ** | −0.084 ** | 0.052 |
| 2. MCS-12 | 49.18 (11.63) | 1 | 0.025 | 0.055 | 0.014 | 0.032 | 0.011 | −0.063 | ||
| 3. WBC (1000/µL) | 5.98 (1.77) | 1 | 0.203 ** | −0.068 * | 0.113 ** | 0.214 ** | 0.083 | |||
| 4. hs-CRP (mg/L) | 1.39 (1.92) | 1 | −0.02 | −0.01 | 0.089 ** | 0.02 | ||||
| 5. TSH (uIU/mL) | 2.80 (5.31) | 1 | −0.300 ** | −0.012 | −0.069 | |||||
| 6. Free T4 (ng/dL) | 1.23 (0.19) | 1 | −0.061 | −0.008 | ||||||
| 7. Insulin (uU/mL) | 8.83 (11.40) | 1 | 0.037 | |||||||
| 8. IGF-1 (ng/mL) | 108.37 (58.52) | 1 | ||||||||
| Pain and fatigue | 1. PCS-12 | 44.99 (8.53) | 1 | −0.006 | −0.033 | −0.011 | 0.029 | −0.045 | −0.036 | −0.005 |
| 2. MCS-12 | 52.98 (9.09) | 1 | 0.047 | 0.003 | −0.057 | 0.04 | 0.027 | 0.075 | ||
| 3. WBC (1000/µL) | 6.05 (1.53) | 1 | 0.191 ** | −0.079 | 0.159 ** | 0.202 ** | 0.014 | |||
| 4. hs-CRP (mg/L) | 1.39 (2.23) | 1 | 0.087 * | −0.068 | 0.004 | −0.057 | ||||
| 5. TSH (uIU/mL) | 2.71 (4.43) | 1 | −0.253 ** | −0.05 | −0.14 | |||||
| 6. Free T4 (ng/dL) | 1.24 (0.21) | 1 | −0.125 ** | 0.135 | ||||||
| 7. Insulin (uU/mL) | 8.08 (9.34) | 1 | 0.021 | |||||||
| 8. IGF-1 (ng/mL) | 123.68 (68.35) | 1 | ||||||||
| Sleep deprivation | 1. PCS-12 | 49.73 (6.53) | 1 | −0.185 ** | −0.016 | −0.086 * | 0.025 | 0.005 | −0.111 ** | 0.077 |
| 2. MCS-12 | 56.09 (7.13) | 1 | −0.022 | 0.048 | 0.025 | −0.019 | 0.037 | −0.114 | ||
| 3. WBC (1000/µL) | 5.83 (1.90) | 1 | 0.175 ** | 0.012 | 0.079 * | 0.197 ** | 0.049 | |||
| 4. hs-CRP (mg/L) | 1.35 (2.07) | 1 | 0.036 | −0.011 | 0.147 ** | −0.039 | ||||
| 5. TSH (uIU/mL) | 2.68 (2.54) | 1 | −0.334 ** | −0.039 | −0.065 | |||||
| 6. Free T4 (ng/dL) | 1.23 (0.20) | 1 | −0.085 * | 0.044 | ||||||
| 7. Insulin (uU/mL) | 7.67 (9.02) | 1 | −0.029 | |||||||
| 8. IGF-1 (ng/mL) | 123.13 (66.12) | 1 | ||||||||
Note: SD, standard deviation; PCS-12, physical component summary of the 12-Item Short Form Health Survey; MCS-12, mental component summary of the 12-Item Short Form Health Survey; WBC, white blood cell; hs-CRP, high sensitivity C reactive protein; TSH, thyroid stimulating hormone; IGF-1, insulin-like growth factor I; * p < 0.05; ** p < 0.01.