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. Author manuscript; available in PMC: 2021 Feb 28.
Published in final edited form as: Nat Microbiol. 2020 Jul 23;5(11):1330–1339. doi: 10.1038/s41564-020-0769-y

Extended Data Fig. 10. Ly6e protects immune cells from mouse hepatitis virus infection.

Extended Data Fig. 10

a-b, Immune cell counts from liver (a) and spleen (b) of MHV-infected or PBS-injected male mice. c-d, Infection of cultured splenocytes from females (c) and males (d) normalized to average (line at 100) of Ly6efl/fl mice. For a-b, n=8 (infected Ly6efl/fl), n=7 (infected Ly6eΔHSC), n=4 PBS-injected from two pooled experiments. For c, n=9 (Ly6efl/fl and Ly6eΔHSC) and n=8 (Ifnar−/−) from four pooled experiments. For d, n=9 (Ly6efl/fl), n=6 (Ly6eΔHSC), or n=6 (Ifnar−/−) mice from four pooled experiments. Statistical significance was determined by one-way ANOVA with Tukey’s multiple comparisons test (a-d). For box plots, center line indicates mean and upper and lower bounds respectively indicate maximum and minimum replicate values (a-b). Data are presented as mean values ± SD (a-d). P values (top-bottom, then left-right): a, *** p=0.0008; **** p=5.6844 × 10−7, **** p=3.1123 × 10−6, **** p=2.337 × 10−5, *** p=0.0002; **** p=1.7135 × 10−5, *** p=0.0001, * p=0.0216, ** p =0.0075, * p=0.0494; *** p=0.0002, *** p=0.0002, ns p=0.9999, * p=0.0182; *** p=0.0004, *** p=0.0008, **** p=7.354 × 10−5; ** p=0.0011, * p=0.0421, * p=0.0160, b, * p=0.0215; * p=0.0449; ** p=0.0081, ** p=0.0022, * p=0.0131; ** p=0.0044, * p=0.0299; * p=0.0179, * p=0.0194; *** p=0.0007. c, * p=0.0288; d, * p=0.0104; * p=0.0240.