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. 2021 Feb 15;8:585358. doi: 10.3389/fmed.2021.585358

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Copyright © 2021 Wang, Wang, Sun, Zhang, Ji, Zhang, Cheng, Li, Xiao, Zhu, Zhong, Ruan, Li, Ren, Ou, Xiao, Li, Deng, Zhong, Li, Wang, Zhang, Chen, Zhu, Xu, Jin, Zhao, Zhong, Zhang, Zhao, Li and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Allele frequency changes of transmission pairs. (A) Box plots showing the alternative allele frequency (AAF) distribution of synonymous and non-synonymous intra-host variants. Each dot indicates the median AAF of each iSNV sites of samples from same patient. (B) Box plots representing the L1-norm distance distribution among sample pairs. Each dot represents the genetic distance between each sample pair. (C) The AAF of donor iSNVs in transmission pairs. Allele frequencies under 5% and over 95% were adjusted to 0% and 1, respectively. (D) Heatmap representing the alternative allele frequencies (AAFs) of consensus and intra-host single nucleotide variants (iSNVs) of the two transmission pairs.