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. 2020 Sep 1;70(5):915–927. doi: 10.1136/gutjnl-2019-320430

Figure 3.

Figure 3

Compositional (16S rRNA gene) analysis of the intestinal microbiota of acute necrotising pancreatitis (ANP) mice. (A) Beta-diversity of cecal content (CE-C) and cecal tissue (CE-T) microbiota measured by weighted UniFrac. A significant difference in microbial composition was observed in Western-type diet (WD)+ANP cecum tissue versus WD+VEH (vehicle) and standard chow diet (SD)+ANP (4–7 mice per group, p=0.003 by Permutation Multivariate Analysis of Variance test). (B) Alpha diversity of CE-C and CE-T microbiota measured by Shannon index. Significant differences were observed in WD+ANP compared with SD+ANP (CE-C: p=0.009; CE-T: p=0.0043 by Mann-Whitney test). No significant differences were observed in WD+ANP versus WD+VEH. (C) Relative bacterial abundance at the phylum level. (D) Relative abundance at the genus level in CE-C and CE-T. (E) Relative abundance of Escherichia/Shigella genus in cecum mucosa (p=0.015 by Mann-Whitney test). *p<0.05; **p<0.01; ns, not statistically significant.