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. Author manuscript; available in PMC: 2021 Nov 15.
Published in final edited form as: Bioorg Med Chem. 2020 Sep 1;28(22):115734. doi: 10.1016/j.bmc.2020.115734

Figure 1.

Figure 1.

Representative methyl imidazole-derived GSM scaffolds. E2012 was developed by Eisai. PF-06442609 was developed by Pfizer and illustrates that the general GSM tetracyclic system may be fused.25–28