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. Author manuscript; available in PMC: 2021 Nov 15.
Published in final edited form as: Bioorg Med Chem. 2020 Sep 1;28(22):115734. doi: 10.1016/j.bmc.2020.115734

Scheme 7.

Scheme 7.

Reagents and conditions: a) ethylhydrazine oxalate or methylhydrazine, EtOH, reflux, 18 h, 61–66%; b) benzoyl isothiocyanate, acetone, reflux, 3.5 h, 88–96%; c) K2CO3, MeOH, THF, r.t., 18 h, 81–92%.