Table 7.

Pharmacokinetic parameters of test article following single iv and po administration to male CD-1 mice.

Mouse Pharmacokinetics
Cmpd	Route	Dose (mg/kg)	Cmax (ng/mL)	Tmax (hrs)	t1/2 (hrs)	AUClast (ng·h/mL)	AUCinf (ng·h/mL)	Cl (mL/hr/kg)	Vss (mL/kg)	F (%)	Brain/Plasma Ratio (1 hr post dose)
46	iv	1	309	0.083	0.65	283	288	3,468	2,826		0.81
	po	5	167	1.0	2.6	639	669			46.4	0.68
59	iv	1	384	0.083	3.84	1,247	1,378	725	3,609		0.62
	po	5	592	2.0	cnda	3,976	cnda			63.8	0.57
60	iv	1	359	0.083	1.6	605	623	1,606	3,640		0.73
	po	5	470	1.0	cnda	1,727	2,369			76.0	0.62
63	iv	1	478	0.083	1.9	723		1,308	3,180		0.21
	po	5	580	1.0	1.6	2,700				74.6	0.22
64	iv	1	549	0.083	0.7	376	383	2,608	2,234		0.37
	po	5	377	0.25	5.3	1,205	1,257			66.0	0.40

^aCannot be determined from data