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. 2021 Feb 15;9:630654. doi: 10.3389/fcell.2021.630654

FIGURE 1.

FIGURE 1

Insulin resistance and Glucose tolerance in CFTR knockout mice. (A) Intraperitoneal insulin tolerance tests were performed in 20-weeks-old male mice WT, HET, and CFTR KO mice. **P < 0.01; NS, not significant. (B) OGTTs were performed in 20-weeks-old male mice WT, HET, and CFTR KO mice. **P < 0.01; NS, not significant. (C) Area under the curve (AUC) of changes in blood glucose levels. (D) Following an injection of 250 mg/ml glucose, serum insulin concentration was measured by ELISA. NS, not significant. (E) Bodyweight was measured in 20-weeks-old male mice WT, HET, and KO mice. Data are mean ± SEM of 7–9 mice per group. **P < 0.01 vs. WT.