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. 2021 Feb 15;9:630654. doi: 10.3389/fcell.2021.630654

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Copyright © 2021 Gu, Zhang, Wu and Gu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CFTR regulates PIP5KA expression and PI(4,5)P₂ concentration. (A) C2C12 myotubes were treated with CFTR inh172, and the concentration of PI(4,5)P₂ was measured by dot blot. **P < 0.01 compared with control (n = 3). (B) The concentration of PI(4,5)P₂ in mice FDB muscle was measured by dot blot. **P < 0.01 compared with control (n = 3). (C) C2C12 myotubes were treated with CFTR inh172, and the protein level of PIP5KA was measured by western blot. **P < 0.01 compared with control (n = 3). (D) The protein level of PIP5KA in mice FDB muscle was measured by western blot. **P < 0.01 compared with control (n = 3).