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. 2021 Feb 15;9:632440. doi: 10.3389/fbioe.2021.632440

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Copyright © 2021 Ragni, Colombini, De Luca, Libonati, Viganò, Perucca Orfei, Zagra and de Girolamo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of RG selection on cartilage and OA-related EV-miRNA profile. (A) PCA for the BMSC- and ASC-EV molecular signature, based on the amount ratios with CC-EVs set as 1, of cartilage-related miRNAs after stable miR-103a-3p and miR-22-5p or unreliable miR-221-3p RG normalization. (B) Effects of RG normalization on the differential expression of single-cartilage-related miRNAs in BMSC- and ASC-EVs with respect to CC-EVs set as 1, N = 3, ^§ p < 0.1, *p < 0.05, **p < 0.01, and ***p < 0.001.