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. 2021 Feb 15;9:639509. doi: 10.3389/fcell.2021.639509

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Copyright © 2021 Yu, Gong, Wu, Dai, Kesteven, Fatkin, Martinac, Graham and Feneley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CaMKIIδ, HDAC4 and MEF2A signaling in response to TAC after 48 h. (A) Representative Western blots of CaMKIIδ, phosphorylated (p-) HDAC4 and total HDAC4 protein expression in the cytoplasm (upper left panel) and in the nucleus (upper right panel). MEF2A blots are shown for the nucleus. (B) Cytoplasmic and nuclear data are normalized with GAPDH and histone, respectively (bottom panels). The HDAC4 cytoplasmic/nuclear (cyto/nuclear) ratio was used as an indicator of HDAC4 nuclear export. All Western blot runs were performed in duplicate or triplicate. Results are presented as the mean value of 3–4 hearts per group ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 vs. sham-operated controls.