Table 2.
Loci associated with S. mansoni infection discovered by linkage studies.
| Phenotypes | Locus name | 5' Marker (Position) | 3'Marker (Position) | References | Candidate genes, Tested (Untested) |
|---|---|---|---|---|---|
| Egg count | SM1 5q31-q33 | D5S642 (128Mb) | D5S412 (158Mb) | (4, 68–70) | IL4, IL5, IL9, IL13, (IL3, CXCL14, CD14, 1IL17B, IL12B) |
| Egg count | 1p21-q23 | D1S236 (95Mb) | D1S196 (168Mb) | (69) | (IL6R, CRP) |
| Egg count | 6p21-q21 | D6S271 (43Mb) | D6S283 (67Mb) | (69) | (VEGFA, IL17A, IL17F) |
| Hepatic fibrosis | SM2 6q22-q23 | D6S1009 (137Mb) | D6S310 (142Mb) | (71) | CTGF, IFNGR1, IL22RA2 |
| Egg count | 7q35-q36 | D7S483 (152Mb) | D7S550 (156Mb) | (69) | (TRB, NOS3, SHH) |
Marker positions are shown in GRCh37 co-ordinates. Candidate genes that have been found associated with the phenotype are shown in bold (Tables 3, 4). Other plausible candidates (See Figure 2) in the regions are in brackets. Genes associated with the Th17 response are underlined. These loci are shown graphically in Figures 1, 2.