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. 2021 Feb 15;12:596169. doi: 10.3389/fgene.2021.596169

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Copyright © 2021 Kang, Jia, Huang, Lu, Chen, Shen, Zou, Wang and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CDK6 is highly expressed in atherosclerosis samples and inhibition of CDK6 reduces cell proliferation in vitro. (A–C) An online data (GSE6088) was analyzed, and CDK6 expression in atherosclerosis was induced by 1.44-fold compared to normal samples (224851_at, 224847_at, and 243000_at). (D,F) RT-PCR analysis of CDK6 mRNA expression levels in HASMC and HUASMC after transfecting with si-CDK6. (E,G) Suppression of CDK6 inhibited cell proliferation of VSMCs in HASMC and HUASMC cell. *P < 0.05.