Table 1.
Strategy | Immunization #1 | Immunization #2 | Immunization #3 | |||
---|---|---|---|---|---|---|
DNAa/SAd7b | Proteinc | DNAa/SAd7b | Proteinc | DNAa/SAd7b | Proteinc | |
DNA + Protein |
54wpi_D SIV Gag |
54wpi_D | 54wpi_D SIV Gag |
54wpi_D | 54wpi_D 54wpi_C 54wpi_G |
54wpi_D |
SAd7 + Protein |
54wpi_D SIV Gag |
54wpi_D SIV Gag |
54wpi_D | 54wpi_D |
aDNA plasmid expresses Env gp160 heterotrimer, where each protomer is 160 kDa with an intact cleavage site.
bSAd7 vector expresses Env gp160 heterotrimer, where each protomer is 160 kDa with an intact cleavage site.
cHIV Envelope purified glycoprotein is a trimer, where each protomer is 140 kDa, no cleavage site.