TABLE 1.

Comparison of Surgical Resection and Chemical Injury Models of Liver Regeneration

	PHx	APAP
Timing of injury	Known time of surgery	Undefined
Hepatocyte proliferation	All hepatocytes	Centrilobular, surrounding necrotic zones
Peak hepatocyte proliferation	48 hours	48 hours
Cell cycle	Synchronous	Unsynchronized
Necrosis	Minimal	Significant, widespread
Inflammatory response	Not significant	Extensive

Adapted from Bhushan et al. (2019).^{( 33 )}