TABLE 2.

Manipulation of HSCs and Their Phenotypic Effects

	Method of HSC Inhibition and Injury Model	Functional Impact of HSC Targeting
Shen et al. (2011)( 50 )	Depletion of activated HSCs with gliotoxin APAP‐induced injury in mice	‐Reduced aHSCs (↓α‐SMA) ‐Significantly more necrosis ‐More infiltrating CD45+ cells ‐66% decrease in proliferating hepatocytes ‐Reduced expression of genes usually up‐regulated during liver regeneration (i.e., HGF and EGF)
Pintille et al. (2010)( 49 )	Inhibition of HSC activation with L‐cysteine. 2AAF/PHx injury model in rats	‐11.1‐fold reduction of aHSCs (↓desmin) ‐Reduction in proliferating cells of all lineages ‐Reduced oval cell response
Kalinichenko et al. (2003)( 55 )	Deficient HSC activation in Foxf1‐depleted mice CCl4injury	‐ Defective HSC activation (↓α‐SMA, ↓col) ‐ More severe pericentral necrosis and apoptosis ‐ Increased mortality (seems to be somethingwrong with the table formating here ‐ there is greater spacing between the bullet points in this row of the column and they didnt line up!)
Passino et al. (2007)( 52 )	Defective HSC activation in P75NTR‐/‐ mice Crossed with plg‐/‐ mice (spontaneously develop liver disease)	‐Failure of HSC activation (↓α‐SMA, ↓col) ‐Reduced hepatocyte proliferation (in vivo and in vitro) ‐2/3 reduction of HGF in liver homogenates ‐More severe liver disease and reduced survival

Abbreviation: 2AAF, 2‐acetylaminofluorene.