Table 4.
Clinical Studies with oHSVs in GBM
| oHSV | Combination | Condition | N | Phase | Status | Country | References |
|---|---|---|---|---|---|---|---|
| HSV1716 | N/A | Recurrent malignant glioma | 9 | N/A | Completed | UK | [187] |
| N/A | High-grade glioma | 12 | N/A | Completed | UK | [188] | |
| N/A | High-grade glioma | 12 | N/A | Completed | UK | [186] | |
| Dexamethasone | Refractory or recurrent high-grade glioma | 2 | 1 | Terminated | US | NCT02031965 | |
| G207 | N/A | Recurrent malignant glioma | 21 | 1 | Completed | US | [190] |
| N/A | Recurrent Brain Cancer | 65 | 1b/2 | Completed | US | NCT00028158 | |
| N/A | Recurrent GBM | 6 | 1b | Completed | US | [191] | |
| Radiation | Recurrent malignant glioma | 9 | 1 | Completed | US | [101] | |
| Radiation | Progressive or recurrent supratentorial brain tumors | 12 | 1 | Active, not recruiting | US | [194] NCT02457845 |
|
| Radiation | Recurrent or refractory cerebellar brain tumors | 15 | 1 | Recruiting | US | [196] NCT03911388 |
|
| Radiation | Recurrent high-grade glioma | 30 | 2 | Not yet recruiting | US | NCT04482933 | |
| G47∆ | N/A | Progressive GBM | 21 | 1/2 | Completed recruiting | Japan | UMIN000002661 |
| N/A | Residual or recurrent GBM | 30 | 2 | Completed recruiting | Japan | UMIN000015995 | |
| M032 | N/A | Recurrent/progressive GBM | 36 | 1 | Recruiting | US | NCT02062827 |
| rQNestin34.5v.2 | Cyclophosphamide | Recurrent malignant glioma | 108 | 1 | Recruiting | US | NCT03152318 |
| C134 | N/A | Recurrent GBM | 24 | 1 | Active, not recruiting | US | NCT03657576 |
Abbreviations: N, number of participants; N/A, not applicable.