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. 2021 Feb 24;16:1405–1422. doi: 10.2147/IJN.S291090

Figure 4.

Figure 4

Distribution of free IG, IG-loaded pH-sensitive NPs (PNPs), IG-loaded time-dependent NPs (TNPs) and IG-loaded dual-functional NPs (DFNPs) in different tissues at 24 h (A) and 48 h (B) post administration.

Notes: § p < 0.05, §§ p < 0.01 TNPs vs free IG; ☆ p < 0.05, ☆☆ p < 0.01 PNPs vs free IG; # p < 0.05, DFNPs vs free IG; ** p < 0.01 PNPs vs TNPs; ★★ p < 0.01 PNPs vs DFNPs; ※※ p < 0.01 TNPs vs DFNPs.