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. 2021 Feb 24;16:1405–1422. doi: 10.2147/IJN.S291090

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© 2021 Gao et al.

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Representative ex vivo biodistribution of the GIT and live images at 6 h and 12 h after oral administration, evaluating the colon-targeted drug delivery and accumulation potential of DiR-loaded pH-sensitive NPs (PNPs), DiR-loaded time-dependent NPs (TNPs), and DiR-loaded dual-functional NPs (DFNPs), respectively. Ex vivo fluorescence images of organs harvested 6 h (A) after oral administration of DFNPs, PNPs and TNPs, respectively (from left to right). In vivo fluorescence images of animals at 6 h (B) and 12 h (C) after intragastric administration of DFNPs, PNPs and TNPs (from left to right), respectively.