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. 2021 Feb 24;16:1405–1422. doi: 10.2147/IJN.S291090

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© 2021 Gao et al.

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IG-loaded nanoformulations can attenuate macroscopic injury and colon length shortening in DSS-induced colitis. Representative macroscopic analysis and colon length changes of rat colonic tissues are shown in this figure. Rats were orally treated with different NPs at a doses of 30 mg IG/kg once for 14 days after administration of DSS. Remarkably, IG-loaded dual-functional NPs (DFNPs) significantly attenuated the colon length shortening compared with IG-loaded pH-sensitive NPs (PNPs) and IG-loaded time-dependent NPs (TNPs).

Notes: Data are presented as the mean ± SD (n = 6 per group). ## p < 0.01 model group vs the normal control group, ** p < 0.01 TNPs group vs the DSS-induced colitis group, §§ p < 0.01 PNPs group vs TNPs group, and ★★ p < 0.01 DFNPs group vs TNPs group.