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. 2021 Feb 24;14:1239–1248. doi: 10.2147/OTT.S294253

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© 2021 Li et al.

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Combination of AEPS and PD1 antibody inhibited tumor growth in colorectal cancer–xenograft mice. CT26 cells were inoculated to establish the colorectal the cancer-xenograft mouse model, 5 mL/kg•day AEPS was given orally orally, and 10 mg/kg•week anti-PD1 injected intravenously intravenously separately or combined for 28 days. (A) After 28 days, mice were killed and tumors arranged and photographed. (B) Tumor volumes were measured at the indicated times using Vernier calipers: volume = length × width²/2. (C) Average tumor weights were analyzed in each group. (D) Tumor-inhibition rates were calculated in each group: inhibition rate = (tumor weight of control group – tumor weight of experimental group)/tumor weight of control group ×100%. Statistical analysis was performed using Student’s t-test and one-way ANOVA. *P<0.05, **P<0.01 compared to the control group; ^ΔP<0.05, ^ΔΔP<0.01 compared to the combined group.