Table 1.

Log Changes at 24 Hours with Various Concentrations of Linezolid and/or Fosfomycin Against the Strain Resistant to Linezolid

Isolate	Inoculum (cfu/mL)	Time (h)	Log Change[=log10(CFUt)–log10(CFU0)]
			LNE2 mg/L	FOS0.5 mg/L	FOS1 mg/L	FOS2 mg/L	FOS0.5 mg/L+LNE 2 mg/L	FOS1 mg/L + LNE 2 mg/L	FOS2 mg/L+ LNE2 mg/L
29213	~105	24	1.98	2.83	2.38	0.47	−1.18	−1.91	−2.40
L8	~105	24	3.71	2.70	1.67	1.09	−1.32	−2.79	−4.81
L16	~105	24	3.66	2.82	1.67	0.42	0.79	−1.23	−1.82
L32	~105	24	4.23	2.72	2.14	0.11	0.83	−0.91	−1.75

Notes: Underlining indicates synergy (≥2 log10 decrease in the CFU/mL with the combination compared with its most active monotherapy) and bold formatting indicates additivity (1 to<2 log10 decrease in the CFU/mL with the combination compared with its most active monotherapy).

Abbreviations: LNE, linezolid; FOS, fosfomycin; CFU, colony-forming units.