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. 2021 Feb 24;14:639–649. doi: 10.2147/IDR.S290332

Table 2.

Log Changes at 24 Hours with Various Concentrations of Linezolid and/or Fosfomycin Against the Strain Resistant to Fosfomycin

Isolate Inoculum (cfu/mL) Time (h) Log Change[=log10(CFUt)–log10(CFU0)]
FOS1 mg/L LNE1 mg/L LNE2 mg/L LNE4 mg/L LNE1 mg/L +FOS1 mg/L LNE2 mg/L +FOS1 mg/L LNE4 mg/L +FOS1 mg/L
29213 ~105 24 2.38 2.49 1.98 0.47 −1.70 −1.91 −2.43
F64 ~105 24 4.20 4.06 3.45 1.58 2.89 1.49 0.24
F128 ~105 24 4.09 3.55 2.63 1.38 3.02 2.27 0.40
F256 ~105 24 3.94 3.42 2.32 1.06 3.18 2.11 0.56

Notes: Underline value indicates synergy (≥2 log10 decrease in the CFU/mL with the combination compared with its most active monotherapy) and bold formatting indicates additivity (1 to<2 log10 decrease in the CFU/mL with the combination compared with its most active monotherapy).

Abbreviations: LNE, linezolid; FOS, fosfomycin; CFU, colony-forming units.