Table 2.
Log Changes at 24 Hours with Various Concentrations of Linezolid and/or Fosfomycin Against the Strain Resistant to Fosfomycin
| Isolate | Inoculum (cfu/mL) | Time (h) | Log Change[=log10(CFUt)–log10(CFU0)] | ||||||
|---|---|---|---|---|---|---|---|---|---|
| FOS1 mg/L | LNE1 mg/L | LNE2 mg/L | LNE4 mg/L | LNE1 mg/L +FOS1 mg/L | LNE2 mg/L +FOS1 mg/L | LNE4 mg/L +FOS1 mg/L | |||
| 29213 | ~105 | 24 | 2.38 | 2.49 | 1.98 | 0.47 | −1.70 | −1.91 | −2.43 |
| F64 | ~105 | 24 | 4.20 | 4.06 | 3.45 | 1.58 | 2.89 | 1.49 | 0.24 |
| F128 | ~105 | 24 | 4.09 | 3.55 | 2.63 | 1.38 | 3.02 | 2.27 | 0.40 |
| F256 | ~105 | 24 | 3.94 | 3.42 | 2.32 | 1.06 | 3.18 | 2.11 | 0.56 |
Notes: Underline value indicates synergy (≥2 log10 decrease in the CFU/mL with the combination compared with its most active monotherapy) and bold formatting indicates additivity (1 to<2 log10 decrease in the CFU/mL with the combination compared with its most active monotherapy).
Abbreviations: LNE, linezolid; FOS, fosfomycin; CFU, colony-forming units.