Table 3.
PAEs Expressed by S. aureus with Different Levels of Susceptibility to Linezolid and Fosfomycin After 1h of Exposure to Linezolid (4 mg/L) and Fosfomycin (2mg/L), Alone and in Combination
| Resistant to | Level of Resistant (mg/L) | PAE (h) | ||
|---|---|---|---|---|
| Linezolid | Fosfomycin | Combination | ||
| NA | 1.06±0.15 | 1.67±0.19 | 2.96±0.31 | |
| Linezolid | 8 | 0.22±0.07 | 1.66±0.07 | 3.51±0.15 |
| 16 | 0.33±0.12 | 0.79±0.04 | 1.29±0.23 | |
| 32 | 0.12±0.08 | 0.73±0.10 | 0.97±0.11 | |
| Fosfomycin | 64 | 0.21±0.08 | 0.16±0.01 | 0.27±0.07 |
| 128 | 0.00±0.14 | 0.12±0.22 | 0.06±0.08 | |
| 256 | 0.20±0.07 | 0.20±0.14 | 0.36±0.08 |
Note: All data are presented as mean ± SD.
Abbreviations: NA, S. aureus ATCC 29213; PAE, post-antibiotic effect.